Titre
Biomimetic Function of Iron Sulfur Clusters with Alternative Ligands. Model Studies Using Synthetic Analogues - Model Studies Using Synthetic Analogues
Auteur
Bergner, Marie
Langue
anglais
ISBN
9783736996724
Éditeur
Cuvillier Verlag
Prix
€ 52,00(Excl. toute livraison)
Frais de livraison
€ 2,95
Détails
2017 198pp Paperback / softback
Plus d'informations
Annotatie
Iron sulfur clusters are essential cofactors involved in electron transfer, sensing, and catalysis in all three kingdoms of life. While most iron sulfur clusters are ligated by cysteine thiolates, a number of clusters featuring so called alternative ligands such as histidine have been recognized in
Flaptekst
Iron sulfur clusters are essential cofactors involved in electron transfer, sensing, and catalysis in all three kingdoms of life. While most iron sulfur clusters are ligated by cysteine thiolates, a number of clusters featuring so called alternative ligands such as histidine have been recognized in recent years. This work uses synthetic [2Fe-2S] analogues to explore the role alternative ligands play in determining the reactivity of iron sulfur clusters. Isomerization in a homoleptically coordinated cluster utilizing a mixed nitrogen- and sulfur-donating ligand is investigated as a model for ligand rearrangement processes during iron sulfur cluster biogenesis. Furthermore, a high fidelity model system for the asymmetrically ligated [2Fe-2S] cluster of mitoNEET proteins is developed and characterized in detail. This cluster and its homoleptic analogue are studied as reagents in proton coupled electron transfer processes, highlighting the role asymmetry and reorganization energy play in tuning this reactivity. The effects of the ligation pattern on entropic contributions during reduction are probed by temperature dependent electrochemical measurements. Finally, synthetic [2Fe-2S] clusters are investigated with respect to their reactivity with organic radicals, mimicking the unique reactivity of biotin synthase.
Images
Bij Boekstra koopt u nieuwe boeken tegen de vastgestelde boekenprijs.
Verzendkosten 1,75 euro per zending binnen Nederland, vanaf 19,90 euro GEEN verzendkosten binnen Nederland.
Verzendkosten België 3,95 euro per zending.
Bij bestellingen van 10 euro of minder zijn de verzendkosten hoger; zie vermelding bij het boek.
Speciale verzoeken? Meestal geen punt, vermeld ze in het veld opmerking.
De actuele levertijd kunt u vinden op onze website.
- Ce livre est nouveau
- Conditions d'utilisation
- Après votre commande, vous et Boekstra recevrez un e-mail de confirmation
- Vous traitez directement avec Boekstra. Dans le courrier électronique, vous pouvez trouver le nom et l'adresse de Boekstra
- Boekstra peut demander un prépaiement
- L'acheteur paie les frais de livraison, sauf accord contraire
- Boekwinkeltjes.nl vous réunis uniquement vous et boekstra et n'est pas responsable du traitement de cette commande